Blueberry Scientific Research
Dynamic news about the benefits of blueberries just keeps rolling in!
The following scientific research papers provide more details on the many ways blueberries may promote good health. Click on the category titles to view in-depth blueberry research. When you click a link, you’ll be leaving the USHBC website.
Aging
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Yang H, Pang W, Lu H, Cheng D, Yan X, Cheng Y, Jiang Y. Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice. J Ag Food Chem. 2012 (5): 59:2069-2076.
nih.gov
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Peng C, Zuo Y, Kwan KM, Liang Y, Ma KY, Chan HYE, Huang Y, Yu H, Chen Z. Blueberry extract prolongs lifespan of Drosophila melanogaster. Exp Gerontol. 2012; 47 (2): 170-178
nih.gov
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Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell 2006; 5 (2) :59-68.
nih.gov
Antioxidant Activity
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Wang Y, Chen H, Camp MJ, Ehlenfeldt MK. Genotype and growing season influence blueberry antioxidant capacity and other quality attributes. Int J Food Sci Tech. 2012; 47:1540-1549.
wiley.com
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Sun L, Ding X, Qi J, Yu H, He S, Zhang J, Ge H, Yu B. Antioxidant anthocyanins screening through spectrum-effect relationships and DPPH-HPLC-DAD analysis on nine cultivars of introduced rabbiteye blueberry in China. Food Chem. 2012; 132 (2):759-765.
usda.gov
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Bornsek SM, Ziberna L, Polak T, Vanzo A, Ulrih NP, Abram V, Tramer F, Passamonti S. Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells. Food Chem. 2012; 134 (4):1878-1884.
nih.gov
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Wang SY, Chen H, Camp MJ, Ehlenfeldt MK. Flavonoid constituents and their contribution to antioxidant activity in cultivars and hybrids of rabbiteye blueberry (Vaccinium ashei Reade). Food Chem. 2012; 132:855-864.
sciencedirect.com
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Wang SY, Camp JM, Ehlenfeldt MK. Antioxidant capacity and -glucosidase inhibitory activity in peel and flesh of blueberry (Vaccinium spp.) cultivars. Food Chem. 2012; 132:1759-1768.
sciencedirect.com
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Johnson MH, de Mejia EG. Comparison of chemical composition and antioxidant capacity of commercially available blueberry and blackberry wines in Illinois. J Food Sci. 2012: 71 (1):C141-148.
nih.gov
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Johnson, MH, Lucius A, Meyer T, Gonzalez de Mejia E. Cultivar evaluation and effect of fermentation on antioxidant capacity and in vitro inhibition of a-amylase and a-glucosidase by highbush blueberry (Vaccinium corombosum). J Agric Food Chem. 2011: 59 (16): 8923-8930.
nih.gov
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Wang SY, Chen H, Ehlenfeldt MK. Antioxidant capacities vary substantially among cultivars of rabbiteye blueberry (Vaccinium ashei Reade). Int J Food Sci Tech. 2011; 46:2482-2490.
wiley.com
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Senevirathne M, Kim S, Jeon Y. Protective effect of enzymatic hydrolysates from highbush blueberry (Vaccinium corymbosum L.) against hydrogen peroxide-induced oxidative damage in Chinese hamster lung fibroblast cell line. Nutr Res Pract. 2010, 4 (3): 1830190.
nih.gov
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Piljac-Zegarac J, Belscak A, Piljac A. Antioxidant capacity and polyphenolic content of blueberry (Vaccinium corymbosum L.) leaf infusions. J Med Food 2009; 12 (3) :608-614.
nih.gov
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Serafini M, Testa MF, Villano D, Pecorari M, van Wieren K, Azzini E, Brambilla A, Maiani G. Antioxidant activity of blueberry fruit is impaired by association with milk. Free Radic Biol Med 2009; 46 (6) :769-774.
nih.gov
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Wang CY, Chen C, Wang SY. Changes of flavonoid content and antioxidant capacity in blueberries after illumination with UV-C. Food Chem 2009; 117 (3) :426-431.
usda.gov
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Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M, Heber D. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem 2008; 56 (4) :1415-22.
nih.gov
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Wang CY, Wang SY, Chen C. Increasing antioxidant activity and reducing decay of blueberries by essential oils. J Agric Food Chem 2008; 56 (10) :3587-92.
nih.gov
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Wolfe KL, Kang X, He X, Dong M, Zhang Q, Liu RH. Cellular antioxidant activity of common fruits. J Agric Food Chem 2008; 56 (18) :8418-26.
nih.gov
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Prior RL, Gu L, Wu X, Jacob RA, Sotoudeh G, Kader AA, Cook RA. Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status. J Am Coll Nutr 2007; 26 (2) :170-81.
nih.gov
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Su M, Chien P. Antioxidant activity, anthocyanins, and phenolics of rabbiteye blueberry (Vaccinium ashei) fluid products as affected by fermentation. Food Chem 2007; 104 (1) :182-7.
usda.gov
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Wu X, Beecher GR, Holden J, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem 2004; 52 (12) :4026-37.
nih.gov
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Wu X, Gu L, Holden J, Haytowitz DB, Gebhardt SE, Beecher G, Prior RL. Development of a database for total antioxidant capacity in foods: a preliminary study. J Food Comp Analysis 2004; 17 (3-4) :407-22.
usda.gov
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Howard LR, Clark JR, Brownmiller C. Antioxidant capacity and phenolic content in blueberries as affected by genotype and growing season. J Sci Food Agric 2003; 83 (12) :1238-47.
wiley.com
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Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard LR, Hampsch-Woodill M, Huang D, Ou B, Jacob RA. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC-FL)) of plasma and other biological and food samples. J Agric Food Chem 2003; 51 (11) :3273-9.
nih.gov
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Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem 2003; 51 (2) :502-9.
nih.gov
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Moyer RA, Hummer KE, Finn CE, Frei B, Wrolstad RE. Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: vaccinium, rubus, and ribes. J Agric Food Chem 2002; 50 (3) :519-25.
nih.gov
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Ehlenfeldt MK, Prior RL. Oxygen radical absorbance capacity (ORAC) and phenolic and anthocyanin concentrations in fruit and leaf tissues of highbush blueberry. J Agric Food Chem 2001; 49 (5) :2222-7.
nih.gov
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Pedersen CB, Kyle J, Jenkinson AM, Gardner PT, McPhail DB, Duthie GG. Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers. Eur J Clin Nutr 2000; 54 (5) :405-8.
nih.gov
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Wang SY, Jiao H. Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem 2000; 48 (11) :5677-84.
nih.gov
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Cao G, Shukitt-Hale B, Bickford PC, Joseph JA, McEwen J, Prior RL. Hyperoxia-induced changes in antioxidant capacity and the effect of dietary antioxidants. J Appl Physiol 1999; 86 (6) :1817-22.
nih.gov
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Prior RL, Cao G, Martin A, Sofic E, McEwen J, O’Brien, C, Lischner N, Ehlenfeldt M, Kalt W, Krewer G, Mainland CM. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J Agric Food Chem 1998; 46 (7) :2686-93.
usda.gov
Bioavailability/Metabolism
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Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolinkowshki GC, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013; 74 (4):1041-1052.
nih.gov
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Del Bo C, Riso P, Brambilla A, Gardana C, Rizzolo A, Simonetti P, Bertolo G, Klimis-Zacas D, Porrini M. Blanching improves anthocyanin absorption from highbush blueberry (Vaccinium corymbosum L.) puree in healthy human volunteers: a pilot study. J Agric Food Chem 2012; 60:9298-9304.
nih.gov
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Milbury PE, Kalt W. Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier. J Agric Food Chem. 2010; 58 (7) :3950-3956.
nih.gov
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Dulebohn RV, Yi W, Srivastava A, Akoh CC, Krewer G, Fischer JG. Effects of blueberry (Vaccinium ashei) on DNA damage, lipid peroxidation, and phase II enzyme activities in rats. J Agric Food Chem 2008; 56 (24) :11700-6.
nih.gov
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Kalt W, Blumberg JB, McDonald JE, Vinquist-Tymchuk MR, Fillmore SAE, Graf BA, O’Leary JM, Milbury PE. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J Agric Food Chem 2008; 56 (3) :705-12.
nih.gov
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Russell WR, Labat A, Scobbie L, Duncan SH. Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications. Mol Nutr Food Res 2007; 51 (6) :726-31.
nih.gov
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Stevenson DE, Cooney JM, Jensen DJ, Zhang J, Wibisono R. Comparison of the relative recovery of polyphenolics in two fruit extracts from a model of degradation during digestion and metabolism. Mol Nutr Food Res 2007; 51 (8) :939-45.
nih.gov
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Yi W, Akoh CC, Fischer J, Krewer G. Absorption of anthocyanins from blueberry extracts by caco-2 human intestinal cell monolayers. J Agric Food Chem 2006; 54 (15) :5651-8.
nih.gov
Bone Health
Brain Function
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Rendeiro C, Vauzour D, Kean RJ, Butler LT, Rattray M, Spencer JPE, Williams CM. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BCNF mRNA expression in young rats. Psychopharmacology 2012; 223:319-330.
nih.gov
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Khanal RC, Howard LR, Wilkes SE, Rogers TJ, Prior RL. Effect of dietary blueberry pomace on selected metabolic factors associated with high fructose feeding in growing sprague-dawley rats. J Med Food. 2012; 15:802-810.
nih.gov
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Miller MG, Shukitt-Hale B. Berry fruit enhances beneficial signaling in the brain. J Ag Food Chem. 2012; 60 (23):5709-5715.
nih.gov
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Devore EE, Kang JH, Breteler MMB, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol 2012; 72 (1): 135-143.
nih.gov
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Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F. Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review. Nutr Neuro. 2011; 14:119-125.
nih.gov
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Malin DH, Lee DR, Goyarzu P, Chang Y-H, Ennis LJ, Becket E, Shukitt-Hale B, Joseph JA. Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition. 2011; 27:338-342.
nih.gov
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Brewer GJ, Torricelli JR, Lindsey AI, Kunz EZ, Neuman A, Fisher DR, Joseph JA. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem. 2010; 21:991-998
nih.gov
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Joseph JA, Bielinkski DF, Fisher DR. Blueberry treatment antagonizes C-2 ceramide-induced stress signaling in muscarinic receptor-transfected COS-7 cells. J Agric Food Chem. 2010; 58 (6) :3380-3392.
nih.gov
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Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. Differential protection among fractionated blueberry polyphenolic families against DA-, AB42-and LPS-induced decrements in Ca2+ buffering in primary hippocampal cells. J Agric Food Chem 2010; 58 (14): 8196-8204
nih.gov
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Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm A. Blueberry supplementation attenuates microglial activation in hippocampla intraocular grafts to aged hosts. Glia 2010, 58 (6) :679-690.
nih.gov
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Berglof E, Small BJ, Bickford PC, Stromberg I. Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts. J Comp Neurol 2009; 515 (1) :72-82.
nih.gov
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Coultrap SJ, Bickford PC, Browning MD. Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP. Age 2008; 30 (4) :263-272.
nih.gov
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Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, DeCabo R, Mouton PR, Shukitt-Hale B, Joseph JA, Ingram DK. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging 2008; 29 (11) :1680-9.
nih.gov
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Joseph JA, Neuman A, Bielinski DF, Fisher DR. Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell. J Alzheimer Dis 2008; 15 (3) :429-441.
nih.gov
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Shukitt-Hale B, Lau FC, Carey AN, Galli RL, Spangler EL, Ingram DK, Joseph JA. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr Neurosci 2008; 11 (4) :172-82.
nih.gov
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Shukitt-Hale B, Lau FC, Joseph JA. Berry fruit supplementation and the aging brain. J Agric Food Chem 2008; 56 (3) :636-41.
nih.gov
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Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, Whiteman M, Spencer JP. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med 2008; 45 :295-305.
nih.gov
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Zhu Y, Bickford PC, Sanberg P, Giunta B, Tan J. Blueberry opposes B-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. Rejuvenation Res 2008; 11 (5) :891-901.
nih.gov
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Joseph JA, Carey A, Brewer GJ, Lau FC, Fisher DR. Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J Alzheimers Dis 2007; 11 (4) :433-46.
nih.gov
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Joseph JA, Shukitt-Hale B, Lau FC. Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann NY Acad Sci 2007; 1100 :470-85.
nih.gov
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Lau FC, Bielinski DF, Joseph JA. Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J Neurosci Res 2007; 85 (5) :1010-7.
nih.gov
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Shukitt-Hale B, Carey AN, Jenkins D, Rabin BM, Joseph JA. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging 2007; 28 (8) :1187-94.
nih.gov
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Yao Y, Vieira A. Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. Neurotoxicology 2007; 28 (1) :93-100.
nih.gov
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Barros D, Amaral OB, Izquierdo I, Geracitano L, do Carmo Bassols Raseira M, Henriques AT, Ramirez MR. Behavioral and genoprotective effects of Vaccinium berries intake in mice. Pharmacol Biochem Behav 2006; 84 (2) :229-34.
nih.gov
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de Rivera C, Shukitt-Hale B, Joseph JA, Mendelson JR. The effects of antioxidants in the senescent auditory cortex. Neurobiol Aging 2006; 27 (7) :1035-44.
nih.gov
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Galli RL, Bielinski DF, Szprengiel A, Shukitt-Hale B, Joseph JA. Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobiol Aging 2006; 27 (2) :344-50.
nih.gov
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Lau FC, Shukitt-Hale B, Joseph JA. Beneficial effects of berry fruit polyphenols on neuronal and behavioral aging. J Sci Food Agric 2006; 86 (14) :2251-5.
usda.gov
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McGuire SO, Shukitt-Hale B, Joseph JA, Hejna MJ, Collier TJ. Dietary supplementation with blueberry extract improves survival of transplanted dopamine neurons. Nutr Neurosci 2006; 9 (5/6) :251-8.
nih.gov
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Joseph JA, Fisher DR, Bielinski D. Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes. J Alzheimers Dis 2006; 9 (1) :35-42.
nih.gov
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Joseph JA, Fisher DR, Carey AN, Bielinski DF. Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract. J Alzheimers Dis 2006; 10 (4) :423-37.
nih.gov
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Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela-Raventos RM, Joseph JA. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci 2005; 8 (2) :111-20.
nih.gov
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Joseph JA, Shukitt-Hale B, Casadesus G, Fisher D. Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochem Res 2005; 30 (6/7) :927-35.
nih.gov
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Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr 2005; 81 (1 Suppl) :313S-6S.
nih.gov
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Lau FC, Shukitt-Hale B, Joseph JA. The beneficial effects of fruit polyphenols on brain aging. Neurobiol Aging 2005; 26S (1) :S128-32.
nih.gov
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Ramirez MR, Izquierdo I, do Carmo Bassols Raseira M, Zuanazzi JA, Barros D, Henriques AT. Effect of lyophilised Vaccinium berries on memory, anxiety and locomotion in adult rats. Pharmcol Res 2005; 52 (6) :457-62.
nih.gov
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Shukitt-Hale B, Galli RL, Meterko V, Carey A, Bielinski DF, McGhie T, Joseph JA. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Age 2005; 27 (1) :49-57.
usda.gov
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Stromberg I, Gemma C, Vila J, Bickford PC. Blueberry- and spirulina-enriched diets enhance striatal dopamine recovery and induce a rapid, transient microglia activation after injury of the rat nigrostriatal dopamine system. Exp Neurol 2005; 196 (2) :298-307.
nih.gov
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Wang Y, Chang C-F, Chou J, Chen H-L, Deng X, Harvey BK, Cadet JL, Bickford PC. Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage. Exp Neurol 2005; 193 (1) :75-84.
nih.gov
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Willis L, Bickford P, Zaman V, Moore A, Granholm A. Blueberry extract enhances survival of intraocular hippocampal transplants. Cell Transplant 2005; 14 (4) :213-23.
nih.gov
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Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee H-G, Smith MA, Joseph JA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci 2004; 7 (5-6) :309-16.
nih.gov
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Goyarzu P, Malin DH, Lau FC, Taglialatela G, Moon WD, Jennings R, Moy E, Moy D, Lippold S, Shukitt-Hale B, Joseph JA. Blueberry supplemented diet: effects on object recognition memory and nuclear factor-kappa B levels in aged rats. Nutr Neurosci 2004; 7 (2) :75-83.
nih.gov
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Joseph JA, Denisova NA, Arendash G, Gordon M, Diamond D, Shukitt-Hale B, Morgan D. Blueberry supplementation enhances signaling and prevents behavioral deficits in an Alzheimer disease model. Nutr Neurosci 2003; 6 (3) :153-62.
nih.gov
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Bickford PC, Gould T, Briederick L, Chadman K, Pollock A, Young D, Shukitt-Hale B, Joseph JA. Antioxidant-rich diets improve cerebellar physiology and motor learning in aged rats. Brain Res 2000; 866 (1-2) :211-7.
nih.gov
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Youdim KA, Shukitt-Hale B, Martin A, Wang H, Denisova NA, Bickford PC, Joseph JA. Short-term dietary supplementation of blueberry polyphenolics: Beneficial effects on aging brain performance and peripheral tissue function. Nutr Neurosci 2000; 3 :383-97.
nih.gov
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Joseph JA, Shukitt-Hale B, Denisova NA, Bielinski DF, Martin A, McEwen J, Bickford PC. Reversals of age-related declines in neuronal signal transduction, cognitive, and motor behavioral deficits with blueberry, spinach, or strawberry dietary supplementation. J Neurosci 1999; 19 (18) :8114-21.
nih.gov
Cancer
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Ravoori S, Vadhanam MV, Aqil F, Gupta RC. Inhibition of estrogen-mediated mammary tumorigenesis by blueberry and black raspberry. J Ag Food Chem. 2012; 60 (22):5547-5555.
nih.gov
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Adams LS, Kanaya N, Phung S, Liu Z, Chen S. Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J Nutr. 2011; 141 (10): 1805-1812.
nih.gov
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Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res. 2010; 70 (9) :3594-3605.
nih.gov
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Aiyer HS, Gupta RC. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev Res. 2010; 3 (6) :727-737.
nih.gov
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Gordillo G, Fang H, Khanna S, Harper J, Phillips G, Sen CK. Oral administration of blueberry inhibits angiogenic tumor growth and enhances survival of mice with endothelial cell neoplasm. Antioxid Redox Signal 2009; 11 (1) :47-58.
nih.gov
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Wu X, Rahal O, Kang J, Till SR, Prior RL, Simmen RCM. In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats. Nutr Res. 2009; 29 (1) :802-811.
nih.gov
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Aiyer HS, Srinivasan C, Gupta RC. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats. Nutr Cancer 2008; 60 (2) :227-34.
nih.gov
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McDougall GJ, Ross HA, Ikeji M, Stewart D. Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. J Agric Food Chem 2008; 56 (9) :3016-23.
nih.gov
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Boateng J, Verghese M, Shackelford L, Walker LT, Khatiwada J, Ogutu S, Williams DS, Jones J, Guyton M, Asiamah D, Henderson F, Grant L, DeBruce M, Johnson A, Washington S, Chawan CB. Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food Chem Toxicol 2007; 45 (5) :725-32.
nih.gov
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Huang C, Zhang D, Li J, Tong Q, Stoner, G. D. Differential inhibition of UV-induced activation of NFkB and AP-1 by extracts from black raspberries, strawberries, and blueberries. Nutr Cancer 2007; 58 (2) :205-12.
nih.gov
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Neto CC. Cranberry and blueberry: Evidence for protective effects against cancer and vascular disease. Mol Nutr Food Res 2007; 51 (6) :652-64.
nih.gov
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Srivastava A, Akoh CC, Fischer J, Krewer G. Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. J Agric Food Chem 2007; 55 (8) :3180-5.
nih.gov
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Suh N, Paul S, Hao X, Simi B, Xiao H, Rimando AM, Reddy BS. Pterostilbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin Cancer Res 2007; 13 (1) :350-5.
nih.gov
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Wilms LC, Boots AW, deBoer VCJ, Maas LM, Pachen DMFA, Gottschalk RWH, Ketelslegers HB, Godschalk RWL, Haenen GRMM, van Schooten FJ, Kleinjans JCS. Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis 2007; 28 (8) :1800-6.
nih.gov
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Schmidt BM, Erdman JW Jr., Lila MA. Differential effects of blueberry proanthocyanidins on androgen sensitive and insensitive human prostate cancer cell lines. Cancer Lett 2006; 231 (2) :240-6.
nih.gov
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Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem 2006; 54 (25) :9329-39.
nih.gov
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Skupien K, Oszmianski J, Kostrzewa-Nowak D, Tarasiuk J. In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 Cells. Cancer Lett 2006; 236 (2) :282-91.
nih.gov
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Yi W, Akoh CC, Fischer J, Krewer G. Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis. Food Research Intl 2006; 39 (5) :628-38.
usda.gov
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Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Int J Cancer 2005; 114 (4) :628-33.
nih.gov
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Wilms LC, Hollman PCH, Boots AW, Kleinjans JCS. Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutat Res 2005; 582 (1-2) :155-62.
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Yi W, Fischer J, Krewer G, Akoh CC. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J Agric Food Chem 2005; 53 (18) :7320-9.
nih.gov
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Hope Smith S, Tate PL, Huang G, Magee JB, Meepagala KM, Wedge DE, Larcom LL. Antimutagenic activity of berry extracts. J Med Food 2004; 7 (4) :450-5.
PubMed.gov
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Olsson ME, Gustavsson K, Andersson S, Nilsson A, Duan R. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem 2004; 52 (24) :7264-71.
nih.gov
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Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL. Anticarcinogenic activity of strawberry, blueberry, and raspberry extracts to breast and cervical cancer cells. J Med Food 2001; 4 (1) :49-51.
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Cardiovascular/Lipids
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Cassidy A, Mukamal KJ, Liu L, Franz M, Eliassen AH, Rimm EB. High anthocyanin intake is associated with a reduced risk of myocardial infarction in young and middle-aged women. Circulation 2013, 127 (2):188-196.
nih.gov
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Coban J, Evran B, Ozkan F, Cefik A, Dogru-Abbasoglu S, Uysal M. Effect of blueberry feeding on lipids and oxidative stress in the serum, liver and aorta of guinea pigs fed on a high-cholesterol diet. Biosci Biotechnol Biochem. 2013;77 (2):389-391
nih.gov
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Yuji K, Sakaida H, Kai T, Fukuda N, Yukizaki C, Sakai M, Tsubouchi H, Kataoka H. Effect of dietary blueberry (Vaccinium ashei Reade) leaves on serum and hepatic lipid levels in rats. J Oleo Sci. 2013; 62 (2):89-96.
nih.gov
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Horrigan LA, Holohan CA, Lawless GA, Murtagh MA, Williams CT, Webster CM. Blueberry juice causes potent relaxation of rat aortic rings via the activation of potassium channels and the H2S pathway. Food Funct. 2013; 4(3);392-400
nih.gov
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Del Bo C, Riso P, Campolo J, Moller P, Loft S, Klimis-Zacas D, Brambilla A, Rizzolo A, Porrini M. A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutr Res. 2013; (3):220-227.
nih.gov
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Elks CM, Reed SD, Mariappan N, Shukitt-Hale B, Joseph JA, Ingram DK, Francis J. A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS ONE. 2011; 6: (9): e24028.
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Basu A, Du M, Leyva MJ, Sanchez K, Betts NM, Wu M, Aston CE, Lyons TJ. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010, 140: (9) :1582-1587.
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Ahmet I, Spangler E, Shukitt-Hale B, Juhaszova M, Sollott SJ, Joseph JA, Ingram DK, Talan M. Blueberry-enriched diet protects rat heart from ischemic damage. PloS One. 2009, 4:1-10
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McAnulty SR, McAnulty LS, Morrow JD, Khardouni D, Shooter L, Monk J, Gross S, Brown V. Effect of daily fruit ingestion on angiotensin converting enzyme activity, blood pressure, and oxidative stress in chronic smokers. Free Radic Res 2005; 39 (11) :1241
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Sakaida H, Nagao K, Higa K, Shirouchi B, Inoue N, Hidaka F, Kai,T., Yanagita T. Effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo. Biosci Biotechnol Biochem 2007; 71 (9) :2335-7.
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Kim H, Bartley GE, Rimando AM, Yokoyama W. Hepatic gene expression related to lower plasma cholesterol in hamsters fed high-fat diets supplemented with blueberry peels and peel extract. J Agric Food Chem. 2010; 58 (7) :3984-3991.
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Ahmet I, Spangler E, Shukitt-Hale B, Joseph JA, Ingram DK, Talan M. Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats. PloS ONE 2009, 4:e7975
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Kalt W, Foote, Fillmore SAE, Lyon M, Van Lunen TA, McRae KB. Effect of blueberry feeding on plasma lipids in pigs. Br J Nutr 2008; 100 (1) :70-8.
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Nagao K, Higa K, Shirouchi B, Nomura S, Inoue N, Inafuku M, Yanagita T. Effect of Vaccinium ashei reade leaves on lipid metabolism in Otsuka Long-Evans Tokushima fatty rats. Biosci Biotechnol Biochem 2008; 72 (6) :1619-22.
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Kahlon TS, Smith GE. In vitro binding of bile acids by blueberries (Vaccinium spp.), plums (Prunus spp.), prunes (Prunus spp.) strawberries (Fragaria X ananassa), cherries (Malpighia punicifolia), cranberries (Vaccinium macrocarpon) and apples (Malus sylvestris). Food Chem 2007; 100 (3) :1182-7.
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Composition
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Li C, Feng J, Huang W, An X. Composition of polyphenols and antioxidant activity of rabbiteye blueberry (Vaccinium ashei) in Manjing. J Agric Food Chem 2013; 61 (3):523-531.
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Rodriguez-Mateos A, Cifuentes-Gomez T, Tabatabaee S, Lecras C, Spencer JPE. Procyanidin, anthocyanin, and chlorogenic acid contents of highbush and lowbush blueberries. J Ag Food Chem. 2012; 60 (23):5709-5715.
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Wan C, Yuan T, Cirello AL, Seeram NP. Antioxidant and alpha-glucosidase inhibitory phenolics isolated from highbush blueberry flowers. Food Chem. 2012; 135 (3); 1929-1937.
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Muller D, Schantz M, Richling E. High performance liquid chromatography analysis of anthocyanins in bilberries (Vaccinium myrtillus L.), blueberries (Vaccinium corymbosum L.), and corresponding juices. J Food Sci. 2012; 77 (4): C340-345.
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Eichholz I Huyskens-Keil S, Keller A, Ulrich D, Kroh LW, Rohn S. UV_B-induced changes of volatile metabolites and phenolic compounds in blueberries (Vaccinium corymbosum L.). Food Chem. 2011; 126 (1): 60-64
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Gavrilova V, Kajdazanoska M, Gjamovski V, Stefova M. Separation, Characterization and Quantification of Phenolic Compounds in Blueberries and Red and Black Currants by HPLC-DAD-ESI-MS. J Agric Food Chem 2011; 59 (8):4009-4018.
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You Q, Wang B, Chen F, Huang Z, Wang X, Luo PG. Comparison of anthocyanins and phenolics in organically and conventionally grown blueberries in selected cultivars. Food Chem. 2011; 125 (1) :201-208.
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Borges G, Degeneve A, Mullen W, Crozier A. Identification of flavonoid and phenolic antioxidants in black currants, blueberries, raspberries, red currants, and cranberries. J Agric Food Chem. 2010; 58 (7) :3901-3909
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Phillips MM, Case RJ, Rimmer CA, Sander LC, Sharpless KE, Wise SA, Yen JH. Determination of organic acids in Vaccinium berry standard reference materials. Anal Bioanal Chem. 2010; 398 (1) :425-434
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Burdulis D, Sarkinas A, Jasutiene I, Stackeviciene E, Nikolajevas L, Janulis V. Comparative study of anthocyanin composition, antimicrobial, and antioxidant activity in bilberry (Vaccinium myrtillus L.) and blueberry (Vaccinium corymbosum L.) fruits. Acta Pol Pharm 2009; 66 (4) :399-408.
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Castrejon ADR, Eichholz I, Rohn S, Kroh LW, Huyskens-Keil S. Phenolic profile and antioxidant activity of highbush blueberry (Vaccinium corymbosum L.) during fruit maturation and ripening. Food Chem 2008; 109 (3) :564-72.
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Kalt W, MacKinnon S, McDonald J, Vinqvist M, Craft C, Howell A. Phenolics of Vaccinium berries and other fruit crops. J Sci Food Agric 2008; 88 (1) :68-76.
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Lohachoompol V, Mulholland M, Srzednicki G, Craske J. Determination of anthocyanins in various cultivars of highbush and rabbiteye blueberries. Food Chem 2008; 111 (1) :249-54.
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Riihinen K, Jaakola L, Karenlampi S, Hohtola A. Organ-specific distribtuion of phenolic compounds in bilberry (Vaccinium myrtillus) and ‘northblue’ blueberry (Vaccinium corymbosum x V. angustifolium). Food Chem 2008; 110 (1) :156-60.
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Saftner R, Polashock J, Ehlenfeldt M, Vinyard B. Instrumental and sensory quality characteristics of blueberry fruit from twelve cultivars. Postharvest biology and technology 2008; 49 (1) :19-26.
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Wang SY, Chen C-T, Sciarappa W, Wang CY, Camp MJ. Fruit quality, antioxidant capacity, and flavonoid content of organically and conventionally grown blueberries. J Agric Food Chem 2008; 56 (14) :5788-94.
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Alkharouf NW, Dhanaraj AL, Naik D, Overall C, Matthews BF, Rowland LJ. BBGD: an online database for blueberry genomic data. BMC Plant Biol 2007; 7 (5).
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Kalt W, Howell AB, MacKinnon SL, Goldman IL. Selected bioactivities of Vaccinium berries and other fruit crops in relation to their phenolic contents. J Sci Food Agric 2007; 87 (12) :2279-85.
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Koponen JM, Happonen AM, Mattila PH, Torronen AR. Contents of anthocyanins and ellagitannins in selected foods consumed in Finland. J Agric Food Chem 2007; 55 (4) :1612-9.
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Vicente AR, Ortugno C, Rosli H, Powell ALT, Greve LC, Labavitch JM. Temporal sequence of cell wall disassembly events in developing fruits. 2. Analysis of blueberry (Vaccinium species). J Agric Food Chem 2007; 55 (10) :4125-30.
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Harnly JM, Doherty RF, Beecher GR, Holden JM, Haytowitz DB, Bhagwat S, Gebhardt S. Flavonoid content of U.S. fruits, vegetables, and nuts. J Agric Food Chem 2006; 54 (26) :9966-77.
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Wu X, Beecher GR, Holden JM, Haytowitz DB, Gebhardt SE, Prior RL. Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J Agric Food Chem 2006; 54 (11) :4069-75.
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Cho MJ, Howard LR, Prior RL, Clark JR. Flavonol glycosides and antioxidant capacity of various blackberry and blueberry genotypes determined by high-performance liquid chromatography/mass spectrometry. J Sci Food Agric 2005; 85 (13) :2149-58.
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Parry J, Su L, Luther M, Zhou K, Yurawecz MP, Whittaker P, Yu L. Fatty acid composition and antioxidant properties of cold-pressed marionberry, boysenberry, red raspberry, and blueberry seed oils. J Agric Food Chem 2005; 53 (3) :566-73.
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Silva JL, Marroquin E, Matta FB, Garner JO Jr., Stojanovic J. Physicochemical, carbohydrate and sensory characteristics of highbush and rabbiteye blueberry cultivars. J Sci Food Agric 2005; 85 (11) :1815-21.
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Wu X, R.L. P. Systematic identification and characterization of anthocyanins by HPLC-ESI-MS/MS in common foods in the United States: fruits and berries. J Agric Food Chem 2005; 53 (7) :2589-99.
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Nakajima J, Tanaka I, Seo S, Yamazaki M, Saito K. LC/PDA/ESI-MS profiling and radical scavenging activity of anthocyanins in various berries. J Biomed Biotechnol 2004; 2004 (5) :241-7.
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Rimando AM, Kalt W, Magee JB, Dewey J, Ballington JR. Resveratrol, pterostilbene, and piceatannol in Vaccinium berries. J Agric Food Chem 2004; 52 (15) :4713-9.
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Taruscio TG, Barney DL, Exon J. Content and profile of flavanoid and phenolic acid compounds in conjunction with the antioxidant capacity for a variety of northwest Vaccinium berries. J Agric Food Chem 2004; 52 (10) :3169-76.
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Wu X, Gu L, Holden J, Haytowitz DB, Gebhardt SE, Beecher G, Prior RL. Development of a database for total antioxidant capacity in foods: a preliminary study. J Food Comp Analysis 2004; 17 (3-4) :407-22.
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Howard LR, Clark JR, Brownmiller C. Antioxidant capacity and phenolic content in blueberries as affected by genotype and growing season. J Sci Food Agric 2003; 83 (12) :1238-47.
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Lyons MM, Yu C, Toma RB, Cho SY, Reiboldt W, Lee J, van Breemen RB. Resveratrol in raw and baked blueberries and bilberries. J Agric Food Chem 2003; 51 (20) :5867-70.
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Sanchez-Moreno C, Cao G, Ou B, Prior RL. Anthocyanin and proanthocyanidin content in selected white and red wines. Oxygen radical absorbance capacity comparison with nontraditional wines obtained from highbush blueberry. J Agric Food Chem 2003; 51 (17) :4889-96.
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Sellappan S, Akoh CC, Krewer G. Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries. J Agric Food Chem 2002; 50 (8) :2432-8.
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Kalt W, Ryan DAJ, Duy JC, Prior RL, Ehlenfeldt MK, Vander Kloet SP. Interspecific variation in anthocyanins, phenolics, and antioxidant capacity among genotypes of highbush and lowbush blueberries (Vaccinium section cyanococcus spp.). J Agric Food Chem 2001; 49 (10) :4761-7.
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Prior RL, Lazarus SA, Cao G, Muccitelli H, Hammerstone JF. Identification of procyanidins and anthocyanins in blueberries and cranberries (Vaccinium Spp.) using high-performance liquid chromatography/mass spectrometry. J Agric Food Chem 2001; 49 (3) :1270-6.
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Mazur WM, Uehara M, Wahala K, Adlercreutz H. Phyto-oestrogen content of berries, and plasma concentrations and urinary excretion of enterolactone after a single strawberry-meal in human subjects. Br J Nutr 2000; 83 (4) :381-7.
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Wang J, Kalt W, Sporns P. Comparison between HPLC and MALDI-TOF MS analysis of anthocyanins in highbush blueberries. J Agric Food Chem 2000; 48 (8) :3330-5.
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Hakkinen SH, Karenlampi SO, Heinonen IM, Mykkanen HM, Torronen AR. Content of the flavonols quercetin, myricetin, and kaempferol in 25 edible berries. J Agric Food Chem 1999; 47 (6) :2274-9.
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Kader F, Haluk J-P, Nicolas J-P, Metche M. Degradation of cyanidin 3-glucoside by blueberry polyphenol oxidase: kinetic studies and mechanisms. J Agric Food Chem 1998; 46 (8) :3060-5.
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Diabetes/Insulin Resistance
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Khanal RC, Howard LR, Wilkes SE, Rogers TJ, Prior RL. Effect of dietary blueberry pomace on selected metabolic factors associated with high fructose feeding in growing Sprague-Dawley rats. J Med Foods. 2012; 15 (9); 802-810.
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Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr, 2010, 140: (10) 1764-1768.
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Wedick NM, Pan A, Cassidy A, Rimm EB, Sampson L, Rosner B, Willett W, Hu FB, Sun Q, van Dam RM. Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Am J Nutr Nutr. 2010; 95 (4): 925-933.
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Draelos AD, Yatskayer M, Raab S, Oresajo C. An evaluation of the effect of a topical product containing C-xyloside and blueberry extract on the appearance of type II diabetic skin. J Cosmet Dermatol. 2009, 8:147-151.
PubMed.gov
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Seymour EM, Tanone II Urcuyo-Llanes DE, Lewis SK, Kirakosyan A, Kondoleon MG, Kaufman PB, Bolling SF. Blueberry intake alters skeletal muscle and adipose tissue peroxisome proliferator-activated receptor activity and reduces insulin resistance in obese rats. J Med Food. 2011, 14: (12):1511-1518.
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DeFuria J, Bennett G, Strissel KJ, Perfield JW II, Milbury PE, Greenbery AS, Obin MS. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr 2009; 139 (8) :1510-16.
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Exercise
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McLeay Y, Barnes MJ, Mundel T, Hurst SM, Hurst RD, Stannard SR. Effect of New Zealand blueberry consumption on recovery from eccentric exercise-induced muscle damage. J Int Soc Sports Nutr. 2012; 9 (1):19.
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McAnulty LS, Nieman DC, Dumke CL, Shooter LA, Henson DA, Utter AC, Milne G, McAnulty SR. Effect of blueberry ingestion on natural killer cell counts, oxidative stress, and inflammation prior to and after 2.5h of running. Appl Physiol Nutr Metab 2011, 36:(6) 976-984.
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Hurst RD, Wells RW, Hurst SM, McGhie TK, Cooney JM, Jensen DJ. Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damage in vitro. Mol Nutr Food Res. 2010, 54: (3) :353-363.
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McAnulty SR, McAnulty LS, Nieman DC, Dumke CL, Morrow JD, Utter AC, Henson DA, Proulx WR, George GL. Consumption of blueberry polyphenols reduces exercise-induced oxidative stress compared to vitamin C. Nutr Res 2004; 24 (3) :209-21.
USDA Agricultural Library
Food Safety
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Horm KM, Davidson M, Harte FM, D’Souza DH. Survival and inactivation of human norovirus surrogates in blueberry juice by high-pressure homogenization. Foodborne Pathog Dis 2012; 9 (11):974-979.
nih.gov
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Kim C, Hung Y. Inactivation of E. coli 0157:H7 on blueberries by electrolyzed water, ultraviolet light, and ozone. J Food Sci. 2012; 77 (4): M206-211.
nih.gov
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Kim TJ, Corbitt MP, Silva JL, Wang DS, Jung Y, Spencer B. Optimization of hot water treatment for removing microbial colonies on fresh blueberry surface. J Food Sci. 2011; 76: (6):M353-M360.
nih.gov
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Park YJ, Biswas R, Phillips RD, Chen J. Antibacterial activities of blueberry and muscadine phenolic extracts. J Food Sci. 2011; 76 (2): M101-M105.
nih.gov
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Bialka KL, Demirci A. Decontamination of Escherichia coli 0157:H7 and Salmonella enterica on blueberries using ozone and pulsed UV-light. J Food Sci 2007; 72 (9) :M391-6.
USDA Agricultural Library
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Popa I, Hanson EJ, Todd ECD, Schilder AC, Ryser ET. Efficacy of chlorine dioxide gas sachets for enhancing the microbiological quality and safety of blueberries. J Food Prot 2007; 70 (9) :2084-8.
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Moreno MA, Castell-Perez ME, Gomes C, Da Silva PF, Moreira RG. Quality of electron beam irradiation of blueberries (Vaccinium corymbosum L.) at medium dose levels (1.0-3.2 kGy). Food Sci & Tech. 2007, 40 (7): 1123-1132.
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Wu VCH, Kim B. Effect of a simple chlorine dioxide method for controlling five foodborne pathogens, yeasts and molds on blueberries. Food Microbiology 2007; 24 (7-8) :794-800.
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Sy KV, McWatters KH, Beuchat LR. Efficacy of gaseous chlorine dioxide as a sanitizer for killing Salmonella, yeasts, and molds on blueberries, strawberries, and raspberries. J Food Prot. 2005, 68 (6): 1165-1175.
usda.gov
Gut Health
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Paturi G, Mandimika T, Butts CA, Zhu S, Roy NC, McNabb WC, Ansell J. Influence of dietary blueberry and broccoli on cecal microbiota activity and colon morphology in mdr 1a-/- mice, a model of inflammatory bowel diseases. Nutrition 2012; 28 (3): 324-330.
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Osman N, Adawi D, Ahrne S, Jeppsson B, Molin G. Probiotics and blueberry attenuate the severity of dextran sulfate sodium (DSS)-induced colitis. Dig Dis Sci 2008; 53 (9) :2464-73.
nih.gov
Liver
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Wang Y, Cheng M, Zhang B, Nie F, Jiang H. Dietary supplementation of blueberry juice enhances hepatic expression of metallothionein and attenuates liver fibrosis in rats. PLoS One 2013 (3):e58659.
nih.gov
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Wang Y, Cheng M, Zhang B, Mu M, Wu J. Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats. World J Gastroent. 2010, 16: (21): 2657-2663
PubMed.gov
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Wang Y, Cheng M, Zhang B, Mu M, Zhou M, Wu J, Li C. Effect of blueberry on hepatic and immunological functions in mice. Hepatobiliary Pancreat Dis Int. 2010, 9: (2):164-168.
PubMed.gov
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Takeshita M, Ishida Y, Akamatsu E, Ohmori Y, Sudoh M, Uto H, Tsubouchi H, Kataoka H. Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. J Biol Chem 2009; 284 (32) :21165-21176.
PubMed.gov
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Osman N, Adawi D, Ahrne S, Jeppsson B, Molin G. Endotoxin- and D-galactosamine-induced liver injury improved by the administration of Lactobacillus, Bifidobacterium and blueberry. Dig Liver Dis 2007; 39 (9) :849-56.
nih.gov
Obesity
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Moghe SS, Juma S, Imrhan V, Vijayagopal P. Effect of blueberry polyphenols on 3T3-F442A preadipocyte differentiation. J Med Food. 2012; 15 (5):448-452.
nih.gov
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Prior RL, Wilkes SE, Rogers TR, Khanal RC, Wu X, Howard LR. Purified blueberry anthocyanins and blueberry juice alter development of obesity in mice fed an obesogenic high-fat diet. J Agric Food Chem. 2010; 58 (7) :3970-3976.
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Molan AL, Lila MA, Mawson J. Satiety in rats following blueberry extract consumption induced by appetite-suppressing mechanisms unrelated to in vitro or in vivo antioxidant capacity. Food Chem 2008; 107 (3) :1039-44.
usda.gov
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Prior RL, Wu X, Gu L, Hager TJ, Hager A, Howard LR. Whole berries versus berry anthocyanins: interactions with dietary fat levels in the C57BL/6J mouse model of obesity. J Agric Food Chem 2008; 56 (3) :647-53.
PubMed.gov
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Tsuda T. Regulation of adipocyte function by anthocyanins; possibility of preventing the metabolic syndrome. J Agric Food Chem 2008; 56 (3) :624-6.
nih.gov
Storage & Processing
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Howard LR, Prior RL, Liyanage R, Lay JO. Processing and storage effect on berry polyphenols: Challenges and implications for bioactive properties. J Ag Food Chem. 2012; 60 (27):6678-6693.
nih.gov
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Barba FJ, Jager H, Meneses N, Esteve MJ, Frigola A, Knorr D. Evaluation of quality changes of blueberry juice during refrigerated storage after high-pressure and pulsed electric fields processing. Innov Food Sci Emerging Tech. 2012; 14:18-24.
sciencedirect.com
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Syamaladevi RM, Andrews PK, Davies NM, Walters T, Sabiani SS. Storage effects on anthocyanins, phenolics and antioxidant activity of thermally processed conventional and organic blueberries. J Sci Food Agric 2012; 92 (4): 916-924.
nih.gov
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Chiabrando V, Giacalone G. Shelf-life extension of highbush blueberry using 1-methylcyclopropene stored under air and controlled atmosphere. Food Chem. 2011; 126 (4): 1812-1816.
USDA.gov
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Duan J, Wu R, Strik BC, Zhao Y. Effect of edible coatings on the quality of fresh blueberries (Duke and Elliott) under commercial storage conditions. Postharvest Biol Tech. 2011; 59:71-79.
usda.gov
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Almenar E, Samsudin H, Auras R, Harte J. Consumer acceptance of fresh blueberries in bio-based packages. J Sci Food Agric. 2010, 90:1121-1128.
nih.gov
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Buckow R, Kastell A, Terefe NS, Cersteeg C. Pressure and temperature effects on degradation kinetics and storage stability of total anthocyanins in blueberry juice. J Agric Food Chem. 2010, 58 (18): 10076-10084.
PubMed.gov
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Chakraborty M, Savarese M, Harbertson E, Harbertson J, Ringer KL. Effect of the novel radiant zone drying method on anthocyanins and phenolics of three blueberry liquids. J Ag Food Chem. 2010; 58 (1) :324-330.
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Howard LR, Castrodale C, Brownmiller C, Mauromoustakos A. Jam processing and storage effects on blueberry polyphenolics and antioxidant capacity. J Agric Food Chem. 2010, 58 (7) :4022-4029.
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Kechinski CP, Guimaraes PVR, Norena CPZ, Tessaro IC, Marczak LDF. Degradation kinetics of anthocyanin in blueberry juice during thermal treatment. J Food Sci. 2010; 75 (2) :C173-C176.
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Oliveira C, Amaro LF, Pinho O, Ferreira IM. Cooked blueberries: Anthocyanin and anthocyanidin degradation and their radical-scavenging activity. J Agric Food Chem. 2010, 58 (16) :9006-9012.
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Sablani SS, Andrews PK, Davies NM, Walters T, Saez H, Syamaladevi RM, Mohekar PR. Effect of thermal treatments on phytochemicals in conventionally and organically grown berries. J Sci Food Agric. 2010, 90 (5) :769-778.
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Brownmiller C, Howard LR, Prior RL. Processing and storage effects on procyanidin composition and concentration of processed blueberry products. J Agric Food Chem 2009; 57 (5) :1896-1902.
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Duarte C, Guerra M, Daniel P, Lopez Camelo A, Yommi A. Quality changes of highbush blueberries fruit stored in CA with different CO2 levels. J Food Sci 2009; 74 (4) :S154-S159.
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Chiabrando V, Giacalone G, Rolle L. Mechanical behaviour and quality traits of highbush blueberry during postharvest storage. J Sci Food Agric 2009; 89 (6) :989-92.
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Almenar E, Samsudin H, Auras R, Harte B, Rubino M. Postharvest shelf life extension of blueberries using a biodegradable package. Food Chem 2008; 110 (1) :120-7.
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Brambilla A, Lo Scalzo R, Bertolo G, Torreggiani D. Steam-blanched highbush blueberry (Vaccinium corymbosum L.) juice: phenolic profile and antioxidant capacity in relation to cultivar selection. J Agric Food Chem 2008; 56 (8) :2643-8.
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Fan L, Forney CF, Song J, Doucette C, Jordan MA, McRae KB, Walker BA. Effect of hot water treatments on quality of highbush blueberries. J Food Sci 2008; 73 (6) :M292-7.
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Brownmiller C, Howard LR, Prior RL. Processing and storage effects on monomeric anthocyanins, percent polymeric color, and antioxidant capacity of processed blueberry products. J Food Sci 2008; 73 (5) :H72-9.
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Perkins-Veazie P, Collins JK, Howard L. Blueberry fruit response to postharvest application of ultraviolet radiation. Postharvest biology and technology 2008; 47 (3) :280-5.
usda.gov
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Trost K, Golc-Wondra A, Prosek M, Milivojevic I. Anthocyanin degradation of blueberry-aronia nectar in glass compared with carton during storage. J Food Sci 2008; 73 (8) :S405-11.
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Shi J, Pan Z, McHugh TH, Wood D, Hirschberg E, Olson D. Drying and quality chraracteristics of fresh and sugar-infused blueberries dried with infrared radiation heating. Food Science and Technology 2008; 41 (10) :1962-72.
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Shi J, Pan Z, McHugh TH, Wood D, Zhu Y, Avena-Bustillos RJ, Hirschberg E. Effect of berry size and sodium hydroxide pretreatment on the drying characteristics of blueberries under infrared radiation heating. J Food Sci 2008; 73 (6) :E259-65.
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Wang CY, Wang SY, Chen C. Increasing antioxidant activity and reducing decay of blueberries by essential oils. J Agric Food Chem 2008; 56 (10) :3587-92.
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Nindo CI, Tang J, Powers JR, Takhar PS. Rheological properties of blueberry puree for processing applications. Food Science and Technology 2007; 40 (2) :292-9.
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Schotsmans W, Molan A, MacKay B. Controlled atmosphere storage of rabbiteye blueberries enhances postharvest quality aspects. Postharvest biology and technology 2007; 44 (3) :277-85.
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Srivastava A, Akoh CC, Yi W, Fischer J, Krewer G. Effect of storage conditions on the biological activity of phenolic compounds of blueberry extract packed in glass bottles. J Agric Food Chem 2007; 55 (7) :2705-13.
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Su M, Chien P. Antioxidant activity, anthocyanins, and phenolics of rabbiteye blueberry (Vaccinium ashei) fluid products as affected by fermentation. Food Chem 2007; 104 (1) :182-7.
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Nindo CI, Tang J, Powers JR, Singh P. Viscosity of blueberry and raspberry juices for processing applications. J Food Engineering 2005; 69 (3) :343-350.
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Schmidt BM, Erdman JW Jr, Lila MA. Effects of food processing on blueberry antiproliferation and antioxidant activity. J Food Sci 2005; 70 (6) :S389-94.
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Lohachoompol V, Srzednicki G, Craske J. The change of total anthocyanins in blueberries and their antioxidant effect after drying and freezing. J Biomed Biotechnol 2004; 2004 (5) :248-52.
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Lee J, Wrolstad RE. Extraction of anthocyanins and polyphenolics from blueberry processing waste. J Food Sci 2004; 69 (7) :C564-73.
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Rossi M, Giussani E, Morelli R, Lo Scalzo R, Nani RC, Torreggiani D. Effect of fruit blanching on phenolics and radical scavenging activity of highbush blueberry juice. Food Research Intl 2003; 36 (9-10) :999-1005.
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Zheng Y, Wang CY, Wang SY, Zheng W. Effect of high-oxygen atmospheres on blueberry phenolics, anthocyanins, and antioxidant capacity. J Agric Food Chem 2003; 51 (24) :7162-9.
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