Blueberry Scientific Research
Dynamic news about the benefits of blueberries just keeps rolling in!
The following scientific research papers provide more details on the many ways blueberries may promote good health. Click on the category titles to view in-depth blueberry research. When you click a link, you’ll be leaving the USHBC website.
Antioxidant Activity
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Johnson, MH, Lucius A, Meyer T, Gonzalez de Mejia E. Cultivar evaluation and effect of fermentation on antioxidant capacity and in vitro inhibition of a-amylase and a-glucosidase by highbush blueberry (Vaccinium corombosum). J Agric Food Chem. 2011: 59 (16): 8923-8930.
PubMed.gov
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Kim TJ, Corbitt MP, Silva JL, Wang DS, Jung Y, Spencer B. Optimization of hot water treatment for removing microbial colonies on fresh blueberry surface. J Food Sci. 2011; 76: (6):M353-M360
PubMed.gov
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Senevirathne M, Kim S, Jeon Y. Protective effect of enzymatic hydrolysates from highbush blueberry (Vaccinium corymbosum L.) against hydrogen peroxide-induced oxidative damage in Chinese hamster lung fibroblast cell line. Nutr Res Pract. 2010, 4 (3): 18
PubMed.gov
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Milbury PE, Kalt W. Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier. J Agric Food Chem. 2010; 58 (7) :3950-3956.
PubMed.gov
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Joseph JA, Bielinkski DF, Fisher DR. Blueberry treatment antagonizes C-2 ceramide-induced stress signaling in muscarinic receptor-transfected COS-7 cells. J Agric Food Chem. 2010; 58 (6) :3380-3392.
PubMed.gov
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Wang CY, Chen C, Wang SY. Changes of flavonoid content and antioxidant capacity in blueberries after illumination with UV-C. Food Chem 2009; 117 (3) :426-431.
USDA Agricultural Library
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Wang SY, Jiao H. Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem 2000; 48 (11) :5677-84.
PubMed.gov
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Moyer RA, Hummer KE, Finn CE, Frei B, Wrolstad RE. Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: vaccinium, rubus, and ribes. J Agric Food Chem 2002; 50 (3) :519-25.
PubMed.gov
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Serafini M, Testa MF, Villano D, Pecorari M, van Wieren K, Azzini E, Brambilla A, Maiani G. Antioxidant activity of blueberry fruit is impaired by association with milk. Free Radic Biol Med 2009; 46 (6) :769-774.
PubMed.gov
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Wang CY, Chen C, Wang SY. Changes of flavonoid content and antioxidant capacity in blueberries after illumination with UV-C. Food Chem 2009; 117 (3) :426-431.
USDA Agricultural Library
Bioavailability/Metabolism
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Kalt W, Blumberg JB, McDonald JE, Vinquist-Tymchuk MR, Fillmore SAE, Graf BA, O’Leary JM, Milbury PE. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J Agric Food Chem 2008; 56 (3) :705-12.
PubMed.gov
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Dulebohn RV, Yi W, Srivastava A, Akoh CC, Krewer G, Fischer JG. Effects of blueberry (Vaccinium ashei) on DNA damage, lipid peroxidation, and phase II enzyme activities in rats. J Agric Food Chem 2008; 56 (24) :11700-6.
PubMed.gov
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Stevenson DE, Cooney JM, Jensen DJ, Zhang J, Wibisono R. Comparison of the relative recovery of polyphenolics in two fruit extracts from a model of degradation during digestion and metabolism. Mol Nutr Food Res 2007; 51 (8) :939-45.
PubMed.gov
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Russell WR, Labat A, Scobbie L, Duncan SH. Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications. Mol Nutr Food Res 2007; 51 (6) :726-31.
PubMed.gov
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Yi W, Akoh CC, Fischer J, Krewer G. Absorption of anthocyanins from blueberry extracts by caco-2 human intestinal cell monolayers. J Agric Food Chem 2006; 54 (15) :5651-8.
PubMed.gov
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Serafini M, Testa MF, Villano D, Pecorari M, van Wieren K, Azzini E, Brambilla A, Maiani G. Antioxidant activity of blueberry fruit is impaired by association with milk. Free Radic Biol Med 2009; 46 (6) :769-774.
PubMed.gov
Brain Function
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Malin DH, Lee DR, Goyarzu P, Chang Y-H, Ennis LJ, Becket E, Shukitt-Hale B, Joseph JA. Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition. 2011; 27:338-342.
PubMed.gov
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Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F. Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review. Nutr Neuro. 2011; 14:119-125.
PubMed.gov
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Malin DH, Lee DR, Goyarzu P, Chang Y-H, Ennis LJ, Becket E, Shukitt-Hale B, Joseph JA. Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition. 2011; 27:338-342.
PubMed.gov
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Brewer GJ, Torricelli JR, Lindsey AI, Kunz EZ, Neuman A, Fisher DR, Joseph JA. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem. 2010; 21:991-998
PubMed.gov
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Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. Differential protection among fractionated blueberry polyphenolic families against DA-, Aand LPS-induced decrements in Ca2+ buffering in primary hippocampa
PubMed.gov
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Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm A. Blueberry supplementation attenuates microglial activation in hippocampla intraocular grafts to aged hosts. Glia 2010, 58 (6) :679-690.
PubMed.gov
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Joseph JA, Bielinkski DF, Fisher DR. Blueberry treatment antagonizes C-2 ceramide-induced stress signaling in muscarinic receptor-transfected COS-7 cells. J Agric Food Chem. 2010; 58 (6) :3380-3392.
PubMed.gov
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Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm A. Blueberry supplementation attenuates microglial activation in hippocampla intraocular grafts to aged hosts. Glia 2010, 58 (6) :679-690.
PubMed.gov
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Coultrap SJ, Bickford PC, Browning MD. Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP. Age 2008; 30 (4) :263-272.
PubMed.gov
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Joseph JA, Neuman A, Bielinski DF, Fisher DR. Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell. J Alzheimer Dis 2008; 15 (3) :429-441.
PubMed.gov
Cancer
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Adams LS, Kanaya N, Phung S, Liu Z, Chen S. Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J Nutr. 2011; 141 (10): 1805-1812.
PubMed.gov
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Adams LS, Kanaya N, Phung S, Liu Z, Chen S. Whole blueberry powder modulates the growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J Nutr. 2011;141(10):1805-1812.
PubMed.gov
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Wu X, Rahal O, Kang J, Till SR, Prior RL, Simmen RCM. In utero and lactational exposure to blueberry via maternal diet promotes mammary epithelial differentiation in prepubescent female rats. Nutr Res. 2009; 29 (1) :802-811.
PubMed.gov
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Adams LS, Phung S, Yee N, Seeram NP, Li L, Chen S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res. 2010; 70 (9) :3594-3605.
PubMed.gov
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Aiyer HS, Gupta RC. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism. Cancer Prev Res. 2010; 3 (6) :727-737.
PubMed.gov
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Wedge DE, Meepagala KM, Magee JB, Smith SH, Huang G, Larcom LL. Anticarcinogenic activity of strawberry, blueberry, and raspberry extracts to breast and cervical cancer cells. J Med Food 2001; 4 (1) :49-51.
PubMed.gov
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Olsson ME, Gustavsson K, Andersson S, Nilsson A, Duan R. Inhibition of cancer cell proliferation in vitro by fruit and berry extracts and correlations with antioxidant levels. J Agric Food Chem 2004; 52 (24) :7264-71.
PubMed.gov
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Hope Smith S, Tate PL, Huang G, Magee JB, Meepagala KM, Wedge DE, Larcom LL. Antimutagenic activity of berry extracts. J Med Food 2004; 7 (4) :450-5.
PubMed.gov
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Adebamowo CA, Cho E, Sampson L, Katan MB, Spiegelman D, Willett WC, Holmes MD. Dietary flavonols and flavonol-rich foods intake and the risk of breast cancer. Int J Cancer 2005; 114 (4) :628-33.
PubMed.gov
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Wilms LC, Hollman PCH, Boots AW, Kleinjans JCS. Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutat Res 2005; 582 (1-2) :155-62.
PubMed.gov
Composition
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You Q, Wang B, Chen F, Huang Z, Wang X, Luo PG. Comparison of anthocyanins and phenolics in organically and conventionally grown blueberries in selected cultivars. Food Chem. 2011; 125 (1) :201-208
USDA.gov
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Gavrilova V, Kajdazanoska M, Gjamovski V, Stefova M. Separation, Characterization and Quantification of Phenolic Compounds in Blueberries and Red and Black Currants by HPLC-DAD-ESI-MS. J Agric Food Chem 2011; 59 (8):4009-4018.
PubMed.gov
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Eichholz I, Huyskens-Keil S, Keller A, Ulrich D, Kroh LW, Rohn S. UV-B-induced changes of volatile metabolites and phenolic compounds in blueberries (Vaccinium corymbosum L.). Food Chem. 2011; 126 (1): 60-64.
USDA.gov
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Phillips MM, Case RJ, Rimmer CA, Sander LC, Sharpless KE, Wise SA, Yen JH. Determination of organic acids in Vaccinium berry standard reference materials. Anal Bioanal Chem. 2010; 398 (1) :425-434
PubMed.gov
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Borges G, Degeneve A, Mullen W, Crozier A. Identification of flavonoid and phenolic antioxidants in black currants, blueberries, raspberries, red currants, and cranberries. J Agric Food Chem. 2010; 58 (7) :3901-3909
PubMed.gov
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Burdulis D, Sarkinas A, Jasutiene I, Stackeviciene E, Nikolajevas L, Janulis V. Comparative study of anthocyanin composition, antimicrobial, and antioxidant activity in bilberry (Vaccinium myrtillus L.) and blueberry (Vaccinium corymbosum L.) fruits. Ac
PubMed.gov
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Burdulis D, Sarkinas A, Jasutiene I, Stackeviciene E, Nikolajevas L, Janulis V. Comparative study of anthocyanin composition, antimicrobial, and antioxidant activity in bilberry (Vaccinium myrtillus L.) and blueberry (Vaccinium corymbosum L.) fruits. Ac
PubMed.gov
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Riihinen K, Jaakola L, Karenlampi S, Hohtola A. Organ-specific distribtuion of phenolic compounds in bilberry (Vaccinium myrtillus) and ‘northblue’ blueberry (Vaccinium corymbosum x V. angustifolium). Food Chem 2008; 110 (1) :156-60.
USDA Agricultural Library
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Castrejon ADR, Eichholz I, Rohn S, Kroh LW, Huyskens-Keil S. Phenolic profile and antioxidant activity of highbush blueberry (Vaccinium corymbosum L.) during fruit maturation and ripening. Food Chem 2008; 109 (3) :564-72.
USDA Agricultural Library
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Wang SY, Chen C-T, Sciarappa W, Wang CY, Camp MJ. Fruit quality, antioxidant capacity, and flavonoid content of organically and conventionally grown blueberries. J Agric Food Chem 2008; 56 (14) :5788-94.
PubMed.gov
Food Safety
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Kim TJ, Corbitt MP, Silva JL, Wang DS, Jung Y, Spencer B. Optimization of hot water treatment for removing microbial colonies on fresh blueberry surface. J Food Sci. 2011; 76: (6):M353-M360.
PubMed.gov
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Park YJ, Biswas R, Phillips RD, Chen J. Antibacterial activities of blueberry and muscadine phenolic extracts. J Food Sci. 2011; 76 (2): M101-M105.
PubMed.gov
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Wu VCH, Kim B. Effect of a simple chlorine dioxide method for controlling five foodborne pathogens, yeasts and molds on blueberries. Food Microbiology 2007; 24 (7-8) :794-800.
USDA Agricultural Library
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Bialka KL, Demirci A. Decontamination of Escherichia coli 0157:H7 and Salmonella enterica on blueberries using ozone and pulsed UV-light. J Food Sci 2007; 72 (9) :M391-6.
USDA Agricultural Library
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Popa I, Hanson EJ, Todd ECD, Schilder AC, Ryser ET. Efficacy of chlorine dioxide gas sachets for enhancing the microbiological quality and safety of blueberries. J Food Prot 2007; 70 (9) :2084-8.
USDA Agricultural Library
Lipids/Obesity
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Ahmet I, Spangler E, Shukitt-Hale B, Joseph JA, Ingram DK, Talan M. Survival and cardioprotective benefits of long-term blueberry enriched diet in dilated cardiomyopathy following myocardial infarction in rats. PloS ONE 2009, 4:e7975
PubMed.gov
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Hurst RD, Wells RW, Hurst SM, McGhie TK, Cooney JM, Jensen DJ. Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damage in vitro. Mol Nutr Food Res. 2010, 54: (3) :353-363.
PubMed.gov
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Wang Y, Cheng M, Zhang B, Mu M, Zhou M, Wu J, Li C. Effect of blueberry on hepatic and immunological functions in mice. Hepatobiliary Pancreat Dis Int. 2010, 9: (2):164-168.
PubMed.gov
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Wang Y, Cheng M, Zhang B, Mu M, Wu J. Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats. World J Gastroent. 2010, 16: (21): 2657-2663
PubMed.gov
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DeFuria J,Bennett G, Strissel KJ, Perfield JW II, MilburyPE, Greenbery AS,Obin MS.
PubMed.gov
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DeFuria J, Bennett G, Strissel KJ, Perfield JW II, Milbury PE, Greenbery AS, Obin MS. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr 2009; 139 (8) :1510-1
PubMed.gov
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Kahlon TS, Smith GE. In vitro binding of bile acids by blueberries (Vaccinium spp.), plums (Prunus spp.), prunes (Prunus spp.) strawberries (Fragaria X ananassa), cherries (Malpighia punicifolia), cranberries (Vaccinium macrocarpon) and apples (Malus sy
USDA Agricultural Library
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Nagao K, Higa K, Shirouchi B, Nomura S, Inoue N, Inafuku M, Yanagita T. Effect of Vaccinium ashei reade leaves on lipid metabolism in Otsuka Long-Evans Tokushima fatty rats. Biosci Biotechnol Biochem 2008; 72 (6) :1619-22.
PubMed.gov
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Molan AL, Lila MA, Mawson J. Satiety in rats following blueberry extract consumption induced by appetite-suppressing mechanisms unrelated to in vitro or in vivo antioxidant capacity. Food Chem 2008; 107 (3) :1039-44.
USDA Agricultural Library
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Kalt W, Foote, Fillmore SAE, Lyon M, Van Lunen TA, McRae KB. Effect of blueberry feeding on plasma lipids in pigs. Br J Nutr 2008; 100 (1) :70-8.
PubMed.gov
Other Health Topics
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Elks CM, Reed SD, Mariappan N, Shukitt-Hale B, Joseph JA, Ingram DK, Francis J. A blueberry-enriched diet attenuates nephropathy in a rat model of hypertension via reduction in oxidative stress. PLoS ONE. 2011; 6: (9): e24028.
PubMed.gov
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Hurst RD, Wells RW, Hurst SM, McGhie TK, Cooney JM, Jensen DJ. Blueberry fruit polyphenolics suppress oxidative stress-induced skeletal muscle cell damage in vitro. Mol Nutr Food Res. 2010, 54: (3) :353-363.
PubMed.gov
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Wang Y, Cheng M, Zhang B, Mu M, Zhou M, Wu J, Li C. Effect of blueberry on hepatic and immunological functions in mice. Hepatobiliary Pancreat Dis Int. 2010, 9: (2):164-168.
PubMed.gov
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Wang Y, Cheng M, Zhang B, Mu M, Wu J. Effects of blueberry on hepatic fibrosis and transcription factor Nrf2 in rats. World J Gastroent. 2010, 16: (21): 2657-2663
PubMed.gov
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Basu A, Du M, Leyva MJ, Sanchez K, Betts NM, Wu M, Aston CE, Lyons TJ. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J Nutr 2010, 140: (9) :1582-1587.
PubMed.gov
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Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women. J Nutr, 2010, 140: (10) 1764-1768.
PubMed.gov
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Ahmet I, Spangler E, Shukitt-Hale B, Juhaszova M, Sollott SJ, Joseph JA, Ingram DK, Talan
PubMed.gov
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Takeshita M, Ishida Y, Akamatsu E, Ohmori Y, Sudoh M, Uto H, Tsubouchi H, Kataoka H.
PubMed.gov
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Takeshita M, Ishida Y, Akamatsu E, Ohmori Y, Sudoh M, Uto H, Tsubouchi H, Kataoka H. Proanthocyanidin from blueberry leaves suppresses expression of subgenomic hepatitis C virus RNA. J Biol Chem 2009; 284 (32) :21165-21176.
PubMed.gov
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Ahmet I, Spangler E, Shukitt-Hale B, Juhaszova M, Sollott SJ, Joseph JA, Ingram DK, Talan M. Blueberry-enriched diet protects rat heart from ischemic damage. PloS One. 2009, 4:1-10
PubMed.gov
Storage & Processing
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Duan J, Wu R, Strik BC, Zhao Y. Effect of edible coatings on the quality of fresh blueberries (Duke and Elliott) under commercial storage conditions. Postharvest Biol Tech. 2011; 59:71-79.
USDA.gov
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Chiabrando V, Giacalone G. Shelf-life extension of highbush blueberry using 1-methylcyclopropene stored under air and controlled atmosphere. Food Chem. 2011; 126 (4): 1812-1816.
USDA.gov
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Oliveira C, Amaro LF, Pinho O, Ferreira IM. Cooked blueberries: Anthocyanin and anthocyanidin degradation and their radical-scavenging activity. J Agric Food Chem. 2010, 58 (16) :9006-9012.
PubMed.gov
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Buckow R, Kastell A, Terefe NS, Cersteeg C. Pressure and temperature effects on degradation kinetics and storage stability of total anthocyanins in blueberry juice. J Agric Food Chem. 2010, 58 (18): 10076-10084.
PubMed.gov
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Almenar E, Samsudin H, Auras R, Harte J. Consumer acceptance of fresh blueberries in bio-based packages. J Sci Food Agric. 2010, 90:1121-1128.
PubMed.gov
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Howard LR, Castrodale C, Brownmiller C, Mauromoustakos A. Jam processing and storage effects on blueberry polyphenolics and antioxidant capacity. J Agric Food Chem. 2010, 58 (7) :4022-4029.
PubMed.gov
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Sablani SS, Andrews PK, Davies NM, Walters T, Saez H, Syamaladevi RM, Mohekar PR. Effect of thermal treatments on phytochemicals in conventionally and organically grown berries. J Sci Food Agric. 2010, 90 (5) :769-778.
PubMed.gov
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Kechinski CP, Guimaraes PVR, Norena CPZ, Tessaro IC, Marczak LDF. Degradation kinetics of anthocyanin in blueberry juice during thermal treatment. J Food Sci. 2010; 75 (2) :C173-C176.
USDA Agricultural Library
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Chakraborty M, Savarese M, Harbertson E, Harbertson J, Ringer KL. Effect of the novel radiant zone drying method on anthocyanins and phenolics of three blueberry liquids. J Ag Food Chem. 2010; 58 (1) :324-330.
PubMed.gov
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Duarte C, Guerra M, Daniel P, Lopez Camelo A, Yommi A. Quality changes of highbush blueberries fruit stored in CA with different CO2 levels. J Food Sci 2009; 74 (4) :S154-S159.
USDA Agricultural Library