Blueberry Research
The following scientific research papers provide more details on the role that blueberries may play in promoting good health. Click on the category titles to view in-depth blueberry research. When you click a link, you’ll be leaving the USHBC website.
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Wang H, Liu J, Li T, Liu RH. Blueberry extract promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans. Food Funct. 2018; 9:5273-5282.
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Schrader MA, Hilton J, Gould R, Kelly VE. Effects of blueberry supplementation on measures of functional mobility in older adults. Appl Physiol Nutr Metab. 2015; 40(6):543-549.
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Yang H, Pang W, Lu H, Cheng D, Yan X, Cheng Y, Jiang Y. Comparison of metabolic profiling of cyanidin-3-O-galactoside and extracts from blueberry in aged mice. J Ag Food Chem. 2012; 59(5):2069-2076.
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Peng C, Zuo Y, Kwan KM, Liang Y, Ma KY, Chan HYE, Huang Y, Yu H, Chen Z. Blueberry extract prolongs lifespan of Drosophila melanogaster. Exp Gerontol. 2012; 47(2):170-178.
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Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans. Aging Cell. 2006; 5(2):59-68.
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Lagha AB, LeBel G, Grenier D. Dual action of highbush blueberry proanthocyanidins on Aggregatibacter actinomycetemcomitans and the host inflammatory response. BMC Complement Altern Med. 2018; 18(1):10.
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Shen X, Sun X, Xie Q, Liu H, Zhao Y, Pan Y, Hwang C, Wu VCH. Antimicrobial effect of blueberry (Vaccinium corymbosum L.) extracts against the growth of Listeria monocytogenes and Salmonella Enteritidis. Food Control. 2014; 35:159-165.
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Salaheen S, Almario JA, Biswas D. Inhibition of growth and alteration of host cell interactions of Pasteurella multocida with natural byproducts. Poult Sci. 2014; 93(6):1375-1382.
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Park YJ, Biswas R, Phillips RD, Chen J. Antibacterial activities of blueberry and muscadine phenolic extracts. J Food Sci. 2011; 76(2):M101-M105.
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Ofek I, Goldhar J, Sharon N. Anti-escherichia coli adhesin activity of cranberry and blueberry juices. Adv Exp Med Biol. 1996; 408:179-83.
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Ma L, SunZ, Zeng Y, Luo M, Yang J. Molecular Mechanism and Health Role of Functional Ingredients in Blueberry for Chronic Disease in Human Beings. Int J Mol Sci. 2018; 19(9):E2785.
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Kim M, Na H, Kasai H, Kawai K, Li Y, Yang M. Comparison of blueberry (Vaccinium spp.) and vitamin C via antioxidative and epigenetic effects in human. J Cancer Prev. 2017; 22(3):174-181.
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Nair AR, Manappan N, Stull AJ, Francis J. Blueberry supplementation attenuates oxidative stress within monocytes and modulates immunce cell levels in adults with metabolic ksyndrome: a randomized, double-blind, placebo-controlled trial. Food Funct. 2017; 8(11):4118-4128.
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Wang H, Guo X, Hu X, Li T, Fu X, Liu RH. Comparison of phytochemical profiles, antioxidant and cellular antioxidant activities of different varieties of blueberry (Vaccinium spp.). Food Chem. 2017; 217:773-781.
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Huang W, Zhu Y, Li CH, Sui Z, Min W. Effect of blueberry anthocyanins malvidin and glycosides on the antioxidant properties in endothelial cells. Oxid Med Cell Longev. 2016; 2016:1591803.
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Contreras RA, Kohler H, Pizarro M, Zuniga GE. In vitro cultivars of Vaccinium corymbosum L. (Ericaceae) are a source of antioxidant phenolics. Antioxidants. 2015; 4(2):281-292.
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Diaconeasa Z, Leopold L, Rugina D, Ayvaz H, Socaciu C. Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice. Int J Mol Sci. 2015; 16(2):2352-2365.
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Pranprawit A, Heyes JA, Molan AL, Kruger MC. Antioxidant activity and inhibitory potential of blueberry extracts against key enzymes relevant for hyperglycemia. J Food Biochem. 2015; 39(1):109-118.
Journal of Food Biochemistry
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Kraujalyte V, Venskutonis PR, Pukalskas A, Cesoniene L, Daubaras R. Antioxidant properties, phenolic composition and potentiometric sensor array evaluation of commercial and new blueberry (Vaccinium corymbosum) and bog blueberry (Vaccinium uliginosum) genotypes. Food Chem. 2015; 188:583-590.
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Diaconeasa Z, Leopold L, Rugina D, Ayvaz H, Socaciu C. Antiproliferative and antioxidant properties of anthocyanin rich extracts from blueberry and blackcurrant juice. Int J Mol Sci. 2015; 16(2):2352-2365.
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Tan D, Liu Y, Shi L, Li B, Liu L, Bai B, Megn X, Hou M, Liu X, Sheng L, Luo X. Blueberry anthocyanins-enriched extracts attenuate the cyclophosphamide-induced lung toxicity. Chem Biol Interact. 2014; 222:106-111.
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Blacker BC, Snyder SM, Eggett DI, Parker TL. Consumption of blueberries with a high-carbohydrate, low-fat breakfast decreases postprandial serum markers of oxidation. Br J Nutr. 2013; 109(9):1670-1677.
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Wang SY, Camp JM, Ehlenfeldt MK. Antioxidant capacity and -glucosidase inhibitory activity in peel and flesh of blueberry (Vaccinium spp.) cultivars. Food Chem. 2012; 132(4):1759-1768.
sciencedirect.com
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Wang SY, Chen H, Camp MJ, Ehlenfeldt MK. Flavonoid constituents and their contribution to antioxidant activity in cultivars and hybrids of rabbiteye blueberry (Vaccinium ashei Reade). Food Chem. 2012; 132(2):855-864.
sciencedirect.com
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Johnson MH, de Mejia EG. Comparison of chemical composition and antioxidant capacity of commercially available blueberry and blackberry wines in Illinois. J Food Sci. 2012; 71(1):C141-148.
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Bornsek SM, Ziberna L, Polak T, Vanzo A, Ulrih NP, Abram V, Tramer F, Passamonti S. Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells. Food Chem. 2012; 134(4):1878-1884.
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Sun L, Ding X, Qi J, Yu H, He S, Zhang J, Ge H, Yu B. Antioxidant anthocyanins screening through spectrum-effect relationships and DPPH-HPLC-DAD analysis on nine cultivars of introduced rabbiteye blueberry in China. Food Chem. 2012; 132(2):759-765.
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Wang Y, Chen H, Camp MJ, Ehlenfeldt MK. Genotype and growing season influence blueberry antioxidant capacity and other quality attributes. Int J Food Sci Tech. 2012; 47:1540-1549.
wiley.com
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Wang SY, Chen H, Ehlenfeldt MK. Antioxidant capacities vary substantially among cultivars of rabbiteye blueberry (Vaccinium ashei Reade). Int J Food Sci Tech. 2011; 46:2482-2490.
wiley.com
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Johnson, MH, Lucius A, Meyer T, Gonzalez de Mejia E. Cultivar evaluation and effect of fermentation on antioxidant capacity and in vitro inhibition of a-amylase and a-glucosidase by highbush blueberry (Vaccinium corombosum). J Agric Food Chem. 2011; 59(16):8923-8930.
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Senevirathne M, Kim S, Jeon Y. Protective effect of enzymatic hydrolysates from highbush blueberry (Vaccinium corymbosum L.) against hydrogen peroxide-induced oxidative damage in Chinese hamster lung fibroblast cell line. Nutr Res Pract. 2010; 4(3):183-90.
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Serafini M, Testa MF, Villano D, Pecorari M, van Wieren K, Azzini E, Brambilla A, Maiani G. Antioxidant activity of blueberry fruit is impaired by association with milk. Free Radic Biol Med. 2009; 46(6):769-74.
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Piljac-Zegarac J, Belscak A, Piljac A. Antioxidant capacity and polyphenolic content of blueberry (Vaccinium corymbosum L.) leaf infusions. J Med Food. 2009; 12(3):608-14.
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Wang CY, Chen C, Wang SY. Changes of flavonoid content and antioxidant capacity in blueberries after illumination with UV-C. Food Chem. 2009; 117(3):426-431.
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Seeram NP, Aviram M, Zhang Y, Henning SM, Feng L, Dreher M, Heber D. Comparison of antioxidant potency of commonly consumed polyphenol-rich beverages in the United States. J Agric Food Chem. 2008; 56(4):1415-22.
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Wolfe KL, Kang X, He X, Dong M, Zhang Q, Liu RH. Cellular antioxidant activity of common fruits. J Agric Food Chem. 2008; 56(18):8418-26.
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Wang CY, Wang SY, Chen C. Increasing antioxidant activity and reducing decay of blueberries by essential oils. J Agric Food Chem. 2008; 56(10):3587-92.
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Su M, Chien P. Antioxidant activity, anthocyanins, and phenolics of rabbiteye blueberry (Vaccinium ashei) fluid products as affected by fermentation. Food Chem. 2007; 104(1):182-7.
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Prior RL, Gu L, Wu X, Jacob RA, Sotoudeh G, Kader AA, Cook RA. Plasma antioxidant capacity changes following a meal as a measure of the ability of a food to alter in vivo antioxidant status. J Am Coll Nutr. 2007; 26(2):170-81.
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Wu X, Gu L, Holden J, Haytowitz DB, Gebhardt SE, Beecher G, Prior RL. Development of a database for total antioxidant capacity in foods: a preliminary study. J Food Comp Analysis. 2004; 17(3-4):407-22.
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Wu X, Beecher GR, Holden J, Haytowitz DB, Gebhardt SE, Prior RL. Lipophilic and hydrophilic antioxidant capacities of common foods in the United States. J Agric Food Chem. 2004; 52(12):4026-37.
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Prior RL, Hoang H, Gu L, Wu X, Bacchiocca M, Howard LR, Hampsch-Woodill M, Huang D, Ou B, Jacob RA. Assays for hydrophilic and lipophilic antioxidant capacity (oxygen radical absorbance capacity (ORAC-FL)) of plasma and other biological and food samples. J Agric Food Chem. 2003; 51(11):3273-9.
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Zheng W, Wang SY. Oxygen radical absorbing capacity of phenolics in blueberries, cranberries, chokeberries, and lingonberries. J Agric Food Chem. 2003; 51(2):502-9.
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Howard LR, Clark JR, Brownmiller C. Antioxidant capacity and phenolic content in blueberries as affected by genotype and growing season. J Sci Food Agric. 2003; 83(12):1238-47.
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Moyer RA, Hummer KE, Finn CE, Frei B, Wrolstad RE. Anthocyanins, phenolics, and antioxidant capacity in diverse small fruits: vaccinium, rubus, and ribes. J Agric Food Chem. 2002; 50(3):519-25.
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Ehlenfeldt MK, Prior RL. Oxygen radical absorbance capacity (ORAC) and phenolic and anthocyanin concentrations in fruit and leaf tissues of highbush blueberry. J Agric Food Chem. 2001; 49(5):2222-7.
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Pedersen CB, Kyle J, Jenkinson AM, Gardner PT, McPhail DB, Duthie GG. Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers. Eur J Clin Nutr. 2000; 54(5):405-8.
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Wang SY, Jiao H. Scavenging capacity of berry crops on superoxide radicals, hydrogen peroxide, hydroxyl radicals, and singlet oxygen. J Agric Food Chem. 2000; 48(11):5677-84.
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Cao G, Shukitt-Hale B, Bickford PC, Joseph JA, McEwen J, Prior RL. Hyperoxia-induced changes in antioxidant capacity and the effect of dietary antioxidants. J Appl Physiol. 1999; 86(6):1817-22.
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Prior RL, Cao G, Martin A, Sofic E, McEwen J, O’Brien C, Lischner N, Ehlenfeldt M, Kalt W, Krewer G, Mainland CM. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of Vaccinium species. J Agric Food Chem. 1998; 46(7):2686-93.
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Langer S, Kennel A, Lodge JK. The influence of juicing on the appearance of blueberry metabolites 2 h after consumption: a metabolite profiling approach. Br J Nutr. 2018; 119:1233-1244.
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Khanal R, Howard LR, Prior RL. Urinary excretion of phenolic acids in rats fed cranberry, blueberry, or black raspberry powder. J Agric Food Chem. 2015; 62(18):3987-3996.
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Hanley MJ, Masse G, Harmatz JS, Cancalon PF, Dolinkowshki GC, Court MH, Greenblatt DJ. Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. Br J Clin Pharmacol. 2013; 74(4):1041-1052.
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Del Bo C, Riso P, Brambilla A, Gardana C, Rizzolo A, Simonetti P, Bertolo G, Klimis-Zacas D, Porrini M. Blanching improves anthocyanin absorption from highbush blueberry (Vaccinium corymbosum L.) puree in healthy human volunteers: a pilot study. J Agric Food Chem. 2012; 60(36):9298-9304.
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Milbury PE, Kalt W. Xenobiotic metabolism and berry flavonoid transport across the blood-brain barrier. J Agric Food Chem. 2010; 58(7):3950-3956.
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Dulebohn RV, Yi W, Srivastava A, Akoh CC, Krewer G, Fischer JG. Effects of blueberry (Vaccinium ashei) on DNA damage, lipid peroxidation, and phase II enzyme activities in rats. J Agric Food Chem. 2008; 56(24):11700-6.
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Kalt W, Blumberg JB, McDonald JE, Vinquist-Tymchuk MR, Fillmore SAE, Graf BA, O’Leary JM, Milbury PE. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J Agric Food Chem. 2008; 56(3):705-12.
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Russell WR, Labat A, Scobbie L, Duncan SH. Availability of blueberry phenolics for microbial metabolism in the colon and the potential inflammatory implications. Mol Nutr Food Res. 2007; 51(6):726-31.
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Stevenson DE, Cooney JM, Jensen DJ, Zhang J, Wibisono R. Comparison of the relative recovery of polyphenolics in two fruit extracts from a model of degradation during digestion and metabolism. Mol Nutr Food Res. 2007; 51(8):939-45.
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Yi W, Akoh CC, Fischer J, Krewer G. Absorption of anthocyanins from blueberry extracts by caco-2 human intestinal cell monolayers. J Agric Food Chem. 2006; 54(15):5651-8.
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Li T, Wu S, Xu Z, Ou-Yang S. Rabbiteye blueberry prevents osteoporosis in ovariectomized rats. J Orthop Surg Res. 2014; 9:56.
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Devareddy L, Hooshmand S, Collins JK, Lucas EA, Chai SC, Arjmandi BH. Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis. J Nutr Biochem. 2008; 19(10):694-9.
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Krishna G, Ying Z, Gomez-Pinilla F. Blueberry supplementation mitigates altered brain plasticity and behavior after traumatic brain injury in rats. Mol Nutr Food Res. 2019.
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McNamara RK, Kalt W, Shidler MD, McDonald J, Summer SS, Stein AL, Stover AN, Krikorian R. Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment. Neurobiol Aging. 2018; 64:147-156.
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Xu N, Meng H, Liu T, Feng Y, Qi Y, Zhang D, Wang H. Blueberry phenolics reduce gastrointestinal infection of patients with cerebral venous thrombosis by improving depressant-induced autoimmune disorder via miR-155-mediated brain-derived neurotrophic factor. Front Pharmacol. 2017; 8:853.
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Hong SM, Soe KH, Lee TH, Kim IS, Lee YM, Lim BO. Cognitive improving effects by highbush blueberry (Vaccinium corymbosum L.) vinegar on scopolamine-induced amnesia mice model. J Agrc Food Chem. 2018; 66(1):99-107.
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Carey AN, Gildawie KR, Rovnak A, Thangthaeng N, Fisher DR, Shukitt-Hale B. Blueberry supplementation attenuates microglia activation and increases neuroplasticity in mice consuming a high-fat diet. Nutr Neurosci. 2019; 22(4):253-263
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Miller MG, Hamilton DA, Joseph JA, Shukitt-Hale B. Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial. Eur J Nutr. 2018; 57(3):1169-1180.
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Boespflug EL, Eliassen JC, Dudley JA, Shidler MD, Kalt W, Summer SS, Stein AL, Stover AN, Krikorian R. Enhanced neural activation with blueberry supplementation in mild cognitive impairment. Nutr Neurosci. 2018; 21(4):297-305.
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Poulose SM, Rabin BM, Bielinski DF, Kelly ME, Miller MG, Thanthaeng N, Dhukitt-Hale B. Neruochemical differences in learning and memory paradigms among rats supplemented with anthocyanin-rich blueberry diets and exposed to acute doses of 56Fe particles. Life Sci Space Res. 2017; 12:16-23.
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Guo Q, Kim Y, Lee B. Protective effects of blueberry drink on cognitive impairment induced by chronic mild stress in adult rats. Nutr Res and Pract. 2017; 11(1):25-32.
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Bowtell JL, Aboo-Bakkar Z, Conway ME, Adlam AR, Fulford J. Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation. Appl Physiol Nutr Metab. 2017; 42(7):773-779.
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Tan L, Yang H, Pang W, Li H, Liu W, Sun S, Song N, Zhang W, Jiang Y. Investigation on the role of BDNF in the benefits of blueberry extracts for the improvement of learning and memory in alzheimer’s diseases mouse model. J Alzheimers Dis. 2017; 56(2):629-640.
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Ebenezer PJ, Wilson CB, Wilson LD, Nair AR, Francis J. The anti-inflammatory effects of blueberries in an animal model of post-traumatic stress disorder (PTSD). PLoS One. 2016; 11(9).
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Shukitt-Hale B, Bielinski DF, Lau FC, Willis LM, Carey AN, Joseph JA. The beneficial effects of berries on cognition, motor behavior and neuronal function in ageing. Br J Nutr. 2015; 114(10):1542-1549.
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Coban J, Dogan-Ekici I, Aydm AF, Betul-Kalaz E, Dogru-Abbasoglu S, Uysal M. Blueberry treatment decreased D-galactose-induced oxidative stress and brain damage in rats. Metab Brain Dis. 2015; 30(3):793-802.
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Whyte AR, Williams CM. Effects of a single dose of a flavonoid-rich blueberry drink on memory in 8 to 10 y old children. Nutrition. 2015; 31(3):531-534.
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Poulose SM, Bielinski DF, Carrihill-Knoll K, Rabin BM, Shukitt-Hale B. Protective effects of blueberry- and strawberry diets on neuronal stress following exposure to 53Fe particles. Brain Res. 2014; 1593:9-18.
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Shukitt-Hale B. Blueberries and neuronal aging. Gerontology. 2012; 58(6):518-523.
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Carey AN, Gomes SM, Shukitt-Hale B. Blueberry supplementation improves memory in middle-aged mice fed a high-fat diet. J Ag Food Chem. 2014; 62(18):3972-3978.
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Whyte AR, Williams CM. The cognitive effects of acute blueberry anthocyanin interventions on 7-9 year old children. Appetite. 2013; 59(2):637.
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Rendeiro C, Vauzour D, Rattray M, Waffo-Teguo P, Merillon JM, Butler LT, Williams CM, Spencer JPE. Dietary levels of pure flavonoids improve spatial memory performance and increase hippocampal brain-derived neurotrophic factor. PLoS One. 2013; 8(5).
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Carey AN, Fisher DR, Rimando AM, Gomes SM, Bielinski DF, Shukitt-Hale B. Stilbenes and anthocyanins reduce stress signaling in BV-2 mouse microglia. J Agric Food Chem. 2013; 61(25):5979-5986.
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Shukitt-Hale B, Lau FC, Cheng V, Luskin K, Carey AN, Carrihill-Knoll K, Rabin BM, Joseph JA. Changes in gene expression in the rat hippocampus following exposure to 56Fe particles and protection by berry diets. Cent Nerv Syst Agents Med Chem. 2013; 13(1):36-42.
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Rendeiro C, Vauzour D, Kean RJ, Butler LT, Rattray M, Spencer JPE, Williams CM. Blueberry supplementation induces spatial memory improvements and region-specific regulation of hippocampal BCNF mRNA expression in young rats. Psychopharmacology. 2012; 223(3):319-330.
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Devore EE, Kang JH, Breteler MMB, Grodstein F. Dietary intakes of berries and flavonoids in relation to cognitive decline. Ann Neurol. 2012; 72(1):135-143.
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Miller MG, Shukitt-Hale B. Berry fruit enhances beneficial signaling in the brain. J Ag Food Chem. 2012; 60(23):5709-5715.
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Malin DH, Lee DR, Goyarzu P, Chang Y-H, Ennis LJ, Becket E, Shukitt-Hale B, Joseph JA. Short-term blueberry-enriched diet prevents and reverses object recognition memory loss in aging rats. Nutrition. 2011; 27(3):338-342.
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Giacalone M, Di Sacco F, Traupe I, Topini R, Forfori F, Giunta F. Antioxidant and neuroprotective properties of blueberry polyphenols: a critical review. Nutr Neuro. 2011; 14(3):119-125.
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Joseph JA, Bielinkski DF, Fisher DR. Blueberry treatment antagonizes C-2 ceramide-induced stress signaling in muscarinic receptor-transfected COS-7 cells. J Agric Food Chem. 2010; 58(6):3380-92.
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Willis LM, Freeman L, Bickford PC, Quintero EM, Umphlet CD, Moore AB, Goetzl L, Granholm A. Blueberry supplementation attenuates microglial activation in hippocampla intraocular grafts to aged hosts. Glia. 2010; 58(6):679-90.
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Joseph JA, Shukitt-Hale B, Brewer GJ, Weikel KA, Kalt W, Fisher DR. Differential protection among fractionated blueberry polyphenolic families against DA-, AB42-and LPS-induced decrements in Ca2+ buffering in primary hippocampal cells. J Agric Food Chem. 2010; 58(14):8196-204.
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Brewer GJ, Torricelli JR, Lindsey AL, Kunz EZ, Neuman A, Fisher DR, Joseph JA. Age-related toxicity of amyloid-beta associated with increased pERK and pCREB in primary hippocampal neurons: reversal by blueberry extract. J Nutr Biochem. 2010; 21(10):991-8.
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Berglof E, Small BJ, Bickford PC, Stromberg I. Beneficial effects of antioxidant-enriched diet for tyrosine hydroxylase-positive neurons in ventral mesencephalic tissue in oculo grafts. J Comp Neurol. 2009; 515(1):72-82.
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Joseph JA, Neuman A, Bielinski DF, Fisher DR. Blueberry antagonism of C-2 ceramide disruption of Ca2+ responses and recovery in MAChR-transfected COS-7 cell. J Alzheimer Dis. 2008; 15(3):429-441.
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Coultrap SJ, Bickford PC, Browning MD. Blueberry-enriched diet ameliorates age-related declines in NMDA receptor-dependent LTP. Age. 2008; 30(4):263-272.
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Zhu Y, Bickford PC, Sanberg P, Giunta B, Tan J. Blueberry opposes B-amyloid peptide-induced microglial activation via inhibition of p44/42 mitogen-activated protein kinase. Rejuvenation Res. 2008; 11(5):891-901.
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Williams CM, El Mohsen MA, Vauzour D, Rendeiro C, Butler LT, Ellis JA, Whiteman M, Spencer JP. Blueberry-induced changes in spatial working memory correlate with changes in hippocampal CREB phosphorylation and brain-derived neurotrophic factor (BDNF) levels. Free Radic Biol Med. 2008; 45(3):295-305.
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Shukitt-Hale B, Lau FC, Carey AN, Galli RL, Spangler EL, Ingram DK, Joseph JA. Blueberry polyphenols attenuate kainic acid-induced decrements in cognition and alter inflammatory gene expression in rat hippocampus. Nutr Neurosci. 2008; 11(4):172-82.
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Shukitt-Hale B, Lau FC, Joseph JA. Berry fruit supplementation and the aging brain. J Agric Food Chem. 2008; 56(3):636-41.
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Duffy KB, Spangler EL, Devan BD, Guo Z, Bowker JL, Janas AM, Hagepanos A, Minor RK, DeCabo R, Mouton PR, Shukitt-Hale B, Joseph JA, Ingram DK. A blueberry-enriched diet provides cellular protection against oxidative stress and reduces a kainate-induced learning impairment in rats. Neurobiol Aging. 2008; 29(11):1680-9.
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Yao Y, Vieira A. Protective activities of Vaccinium antioxidants with potential relevance to mitochondrial dysfunction and neurotoxicity. Neurotoxicology. 2007; 28(1):93-100.
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Joseph JA, Shukitt-Hale B, Lau FC. Fruit polyphenols and their effects on neuronal signaling and behavior in senescence. Ann NY Acad Sci. 2007; 1100:470-85.
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Joseph JA, Carey A, Brewer GJ, Lau FC, Fisher DR. Dopamine and Abeta-induced stress signaling and decrements in Ca2+ buffering in primary neonatal hippocampal cells are antagonized by blueberry extract. J Alzheimers Dis. 2007; 11(4):433-46.
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Shukitt-Hale B, Carey AN, Jenkins D, Rabin BM, Joseph JA. Beneficial effects of fruit extracts on neuronal function and behavior in a rodent model of accelerated aging. Neurobiol Aging. 2007; 28(8):1187-94.
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Lau FC, Bielinski DF, Joseph JA. Inhibitory effects of blueberry extract on the production of inflammatory mediators in lipopolysaccharide-activated BV2 microglia. J Neurosci Res. 2007; 85(5):1010-7.
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McGuire SO, Sortwell CE, Shukitt-Hale B, Joseph JA, Henja MJ, Collier TJ. Dietary supplementation with blueberry extract improves survival of transplanted dopamine neruons. Nutr Neurosci. 2006; 9(5-6):251-258.
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Joseph JA, Fisher DR, Bielinski D. Blueberry extract alters oxidative stress-mediated signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes. J Alzheimers Dis. 2006; 9(1):35-42.
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Lau FC, Shukitt-Hale B, Joseph JA. Beneficial effects of berry fruit polyphenols on neuronal and behavioral aging. J Sci Food Agric. 2006; 86(14):2251-5.
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Joseph JA, Fisher DR, Carey AN, Bielinski DF. Dopamine-induced stress signaling in COS-7 cells transfected with selectively vulnerable muscarinic receptor subtypes is partially mediated via the i3 loop and antagonized by blueberry extract. J Alzheimers Dis. 2006; 10(4):423-37.
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Galli RL, Bielinski DF, Szprengiel A, Shukitt-Hale B, Joseph JA. Blueberry supplemented diet reverses age-related decline in hippocampal HSP70 neuroprotection. Neurobiol Aging. 2006; 27(2):344-50.
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Barros D, Amaral OB, Izquierdo I, Geracitano L, do Carmo Bassols Raseira M, Henriques AT, Ramirez MR. Behavioral and genoprotective effects of Vaccinium berries intake in mice. Pharmacol Biochem Behav. 2006; 84(2):229-34.
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de Rivera C, Shukitt-Hale B, Joseph JA, Mendelson JR. The effects of antioxidants in the senescent auditory cortex. Neurobiol Aging. 2006; 27(7):1035-44.
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Joseph JA, Shukitt-Hale B, Casadesus G, Fisher D. Oxidative stress and inflammation in brain aging: nutritional considerations. Neurochem Res. 2005; 30(6-7):927-35.
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Shukitt-Hale B, Galli RL, Meterko V, Carey A, Bielinski DF, McGhie T, Joseph JA. Dietary supplementation with fruit polyphenolics ameliorates age-related deficits in behavior and neuronal markers of inflammation and oxidative stress. Age. 2005; 27(1):49-57.
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Joseph JA, Shukitt-Hale B, Casadesus G. Reversing the deleterious effects of aging on neuronal communication and behavior: beneficial properties of fruit polyphenolic compounds. Am J Clin Nutr. 2005; 81(1 Suppl):313S-6S.
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